NURR1 Downregulation Favors Osteoblastic Differentiation of MSCs

NURR1 Downregulation Favors Osteoblastic Differentiation of MSCs

Mesenchymal stem cells (MSCs) have been identified in human dental tissues. Dental pulp stem cells (DPSCs) were classified within MSC family, are multipotent, can be isolated from adult teeth, and have been shown to differentiate, under particular conditions, into various cell types including osteoblasts. In this work, we investigated how the differentiation process of DPSCs toward osteoblasts ...

does dna methylation plays a critical role in osteoblastic differentiation of mesenchymal stem cells (mscs)?

Does DNA Methylation Plays a Critical Role in Osteoblastic Differentiation of Mesenchymal Stem Cells (MSCs)?

1 Research Center of Thalassemia and Hemoglobinopathy, Jundishapur University of Medical Sciences, Ahvaz, IR Iran 2 Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran 3 Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands 4 Young Researchers Club, Science and Research Branch, Islamic Azad U...

Chondrogenic differentiation capacity of mechanically stimulated MSCs is increased via downregulation of CD73

INTRODUCTION: The bone regeneration process is characterized by hematoma formation, inflammation, angiogenesis, chondrogenesis, osteogenesis and bone remodeling. Mesenchymal stem cells (MSCs) are crucial during the early phase of bone healing, possibly acting via migration, proliferation and differentiation into functional cells of the chondrogenic or osteogenic lineage. In addition to biologic...

تاثیر داروی زولدرونیک اسید در بیان و متیلاسیون ژن BSP در طول تمایز استئوبلاستیک سلولهای بنیادی مزانشیمی

Background and Aim: Bone sialoprotein (BSP) is a specific marker of osteoblastic differentiation. In this research, the effect of Zoledronic Acid on BSP expression and methylation status during osteoblastic differentiation of mesenchymal stem cells (MSCs) was evaluated. Materials and Methods: In this experimental study, MSCs were isolated from human bone marrow. For osteogenic differentiation,...